Association between rs1800796 polymorphism in the IL-6 gene and the risk of lung cancer: An updated meta-analysis

Abstract

ObjectiveInterleukin-6 (IL-6) rs1800796 gene polymorphism has been demonstrated association with an increased lung cancer risk. However, the evidence from individual studies is inconsistent. MethodsTo explore the relationship between IL-6 rs1800796 gene polymorphism and lung cancer risk, a meta-analysis of 8567 subjects from 12 studies was performed. ResultsIL-6 rs1800796 gene polymorphism was significantly associated with lung cancer in the East Asian population under both the heterozygous (P = .036) and dominant models (P = .039). However, sensitivity analysis suggested a significant association between IL-6 rs1800796 gene polymorphism and lung cancer under the dominant (P < .001), homozygous (P = .022), heterozygous (P < .001), additive (P < .001) and allelic models (P < .001). ConclusionIn the East Asian population, a significant association was found between IL-6 rs1800796 gene polymorphism and lung cancer risk under the recessive genetic and additive genetic models. East Asian carriers of the G allele of the IL-6 rs1800796 gene polymorphism may be at an increased risk of developing lung cancer.