Abstract
Bronchiolitis is the leading cause of hospitalization in US infants.1 Rhinovirus (RV) is the second most common cause of severe bronchiolitis (ie, bronchiolitis requiring hospitalization) following respiratory syncytial virus (RSV).1 RVs are RNA viruses consisting of more than 160 genotypes that are classified into 3 species (RV-A, RV-B, and RV-C).2 RV-A and RV-C are more frequently found than RV-B in children with acute respiratory infections (ARIs) and wheezing illnesses.3,4 Emerging evidence suggests a complex interplay between viral infection, airway microbes, and host immune response in the pathobiology of ARI.
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