Association between retinal microvasculature and optic disc alterations in high myopia

Jiangnan He,Haidong Zou,Jianfeng Zhu,Yao Yin,Ying Fan,Xun Xu,Hongfeng Zhou,Qiuying Chen

doi:10.1038/s41433-019-0438-7

Abstract

PurposeThis study aimed to explore the characteristics of retinal perfusion and its associations with high myopia.MethodsA total of 760 participants were included. Peripapillary radial peripapillary capillary perfusion, foveal avascular zone, and parafoveal perfusion were measured using optical coherence tomography angiography (OCTA). Tilted disc ratio and parapapillary atrophy were determined using swept-source optical coherence tomography.ResultsA total of 760 young healthy participants with myopic eyes were included in the analysis. The mean axial length and titled disc ratio were 26.43 ± 1.14 and 0.76 ± 0.08 mm in the high-myopia group and 24.79 ± 0.75 and 0.80 ± 0.09 mm in the control group, respectively. The high-myopia group exhibited significantly larger parapapillary atrophy, lower tilted disc ratio, lower radial peripapillary capillary vessel density, larger area of foveal avascular zone, and lower deep parafoveal vessel density. In the multivariate analysis, titled disc ratio significantly correlated with radial peripapillary capillary vessel density (P = 0.0134), larger foveal avascular zone (P = 0.0062), and lower deep parafoveal vessel density (P < 0.0001).ConclusionsReduced radial peripapillary capillary and deep parafoveal vessel density and enlarged area of foveal avascular zone were observed in high myopia. Tilted disc ratio correlated with retinal perfusion.

Highlights

Myopia is the leading cause of correctable visual impairment even in younger persons in the world [1]
No significant differences in age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), BP, mean arterial pressure (MAP), PR, and Central corneal thickness (CCT) were found among the four groups
This study found using optical coherence tomography angiography (OCTA) that eyes with high myopia (HM) had a decreased radial peripapillary capillary (RPC) vessel density compared with eyes with EM and MIM, which was in accordance with the findings of previous studies [7, 9, 14, 25,26,27,28,29]

Summary

Introduction

Myopia is the leading cause of correctable visual impairment even in younger persons in the world [1]. It is estimated that by 2050, 5 billion and 1 billion people will be. These authors contributed : Jiangnan He, Qiuying Chen. Association between retinal microvasculature and optic disc alterations in high myopia. Based on this background, this study aimed to investigate the early characteristics of peripapillary and macular retinal perfusion and ocular variables in HM. It focused on the association between vascular parameters and tilted disc ratio in a myopia population

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Conclusion