Association between resistin gene (-420 C>G) polymorphism and acne vulgaris.

Abstract

Acne vulgaris (AV) is the most prevalent inflammatory skin disease and develops on the face and upper trunk. Resistin, a member of the cysteine-rich secretory proteins family, is an adipokine expressed primarily in macrophages and monocytes; it has a role to play in the inflammatory period. This study's purpose was to detect whether known resistin gene (-420 C>G) polymorphism plays a role in the pathogenesis of AV. Patients with AV (n=94) and healthy controls (n=94) were enrolled in this investigation. Resistin gene (-420 C>G) polymorphism was decided by PCR-RFLP procedure. The distribution of genotype frequencies of resistin gene (-420 C>G) polymorphism was significantly different between the AV and healthy controls (p=0.002). We found that the resistin gene (-420 C>G) CG genotype exhibited a significant association with decreased acne vulgaris risk. Our study is the first report investigating the relationship between the risk of AV and resistin gene (-420 C>G) polymorphism in the Turkish population. Resistin gene (-420 C>G) polymorphism is related to AV pathogenesis. CG genotype has a protective role and may be linked to a reduced risk of AV development. Furthermore, studies are needed to verify these findings in other populations.