Association between renal function and chemotherapy-related toxicity in older adults with cancer.

Abstract

9509 Background: Older adults with cancer are at increased risk for chemotherapy-related toxicity (CRT). Tools are needed to better define their risk and aid in treatment planning. Renal function declines with age and can be calculated with various formulas, although the ideal formula for such calculations is unclear. We therefore evaluated the association between renal function and CRT in older adults and compared the effect of different renal function formulas and body weight measurements on this association. Methods: This is a secondary analysis of data from a prospective multicenter study of 500 patients age 65 and older who were starting a new chemotherapy regimen. Renal function was estimated with four formulas (modified Jelliffe [Jelliffe], Cockcroft-Gault [CG], Wright, and Modification of Diet in Renal Disease [MDRD]), using actual, ideal and adjusted body weights. The association between baseline renal function and grade 3-5 CRT was evaluated by unconditional logistic regression. Results: Mean ag...