Abstract
The autonomic dysfunction in palmar hyperhidrosis (PH) includes not only sympathetic overactivity but also parasympathetic impairment. A decrease of parasympathetic tone has been noted in gastroesophageal reflux disease of neonates and adults. Patients with reflux esophagitis have a defective anti-reflux barrier. The association between reflux esophagitis and PH is deliberated in this article. The National Health Insurance Database in Taiwan was used. At first-time visits, PH patients were identified by the International Classification of Disease, 9th Revision, Clinical Modification disease code of 780.8 without endoscopic thoracic sympathectomy. Patients were matched by age and gender as control groups. The reflux esophagitis incidence was assessed using disease codes 530.11, 530.81, and 530.85. The factors related to reflux esophagitis were established by the Cox proportional regression model. The risk of reflux esophagitis in PH patients had a hazard ratio of 3.457 (95% confidence interval: 3.043–3.928) after adjustment of the other factors. We confirmed the association between reflux esophagitis and PH. Health care providers must be alerted to this relationship and other risk factors of reflux esophagitis to support suitable treatments to improve the quality of life of patients.
Highlights
Patients with palmar hyperhidrosis (PH) suffer from over-production of sweat in the palms induced by stress or exercise, which affects quality of life
The occurrence of reflux esophagitis was tracked for a mean of 10.03 follow-up years
Theesophagitis occurrencewas of reflux esophagitis tracked for aatmean
Summary
Patients with palmar hyperhidrosis (PH) suffer from over-production of sweat in the palms induced by stress or exercise, which affects quality of life. A sympathetic overactivity of skin during stimulation by mental and thermal responses in PH patients has been shown [1]. The autonomic dysfunction in PH was found in a previous study to involve sympathetic overactivity combined with parasympathetic impairment [2]. The sympathetic overactivity in PH causes increased risk of cardiovascular disease and ischemic stroke compared with that of sympathectomy patients [3,4,5]. Given the parasympathetic disturbance present in both PH and reflux esophagitis, the relationship of two diseases was worthy of study. Res. Public Health 2020, 17, 4502; doi:10.3390/ijerph17124502 www.mdpi.com/journal/ijerph
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