Abstract
Objective: To investigate the relationship between different glucose metabolism status and Pulse Wave Velocity (PWV)and further explore the relationship between PWV, HOMA-IR and the Framingham risk score of 10-year (FRS). Methods: 105 subjects were divided into three groups: normal glucose tolerance group (G1, n=47); pre-diabetes group (G2, n=32)and type 2 diabetes mellitus (DM) group (G3, n=26)General clinical data and biochemical parameters of each subject were collected. PWV was measured using the Complior SP. FRS was calculated with the lipids excel spreadsheets from Framingham Heart Study homepage. The correlation of different glucose metabolism status, PWV and FRS were analyzed and compared. Results: A positive correlation was found between carotid-to-femoral PWV (cf-PWV) and age, (Systolic Blood Pressure) SBP, 2-hr plasma glucose (2h PG). There is a direct connection between homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-IR (CP). FRS was difference among three groups. A correlation was found between FRS and cf-PWV, 2h PG, HOMA-IR (CP). Conclusion: HOMA-IR (CP) and cf-PWV are positive correlation with FRS, which is a predictor of cardiovascular disease (CVD). Hence HOMA-IR (CP) and cf-PWV may have a good clinical value for indicating vascular structure and function and further evaluating the 10-year risk of CVD.
Highlights
By the end of 2013, diabetes had caused 5.1 million deaths and cost billions for healthcare spending
The research is to investigate the relationship between different glucose metabolism status and PWVand further explore its relationship between Pulse Wave Velocity (PWV), homeostasis model assessment of insulin resistance (HOMA-IR) and Framingham risk score of 10-year (FRS)
impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are strongly associated with excess body weight and insulin resistance, which is the central feature of the metabolic syndrome metabolic abnormalities and leads the path to diabetes
Summary
By the end of 2013, diabetes had caused 5.1 million deaths and cost billions for healthcare spending. Without concerted action to prevent diabetes, there will be 592 million people living with the disease in less than 25 years’ time [1]. Diabetes mellitus and impaired fasting glucose bring carotid arterioles atherosclerosis and draw our attention. The research is to investigate the relationship between different glucose metabolism status and PWVand further explore its relationship between PWV, HOMA-IR and FRS. Pre-diabetes has been first described by the WHO in 1980 as impaired glucose tolerance (IGT) [2]. In order to avoid the time-consuming and somewhat cumbersome measurement of 2h PG, the ADA proposed to identify pre-diabetes as impaired fasting glucose (IFG) in 1997, which relies on one fasting measurement only. IFG and IGT are strongly associated with excess body weight and insulin resistance, which is the central feature of the metabolic syndrome metabolic abnormalities and leads the path to diabetes. We investigated HOMA-IR instead of different glucose values, which are more rational and perfective, and conform to reality
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