Abstract
BackgroundProdynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility.MethodsFour databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software.ResultsA total of seven case-control studies with 3129 cases and 3289 controls were recruited in the meta-analysis. For rs910080, rs1997794, rs1022563, and rs2235749 polymorphisms of PDYN gene, there were six, four, five, and four studies eventually included, respectively. The findings indicated that rs910080 polymorphism was significantly correlated with OD among Asian population under allelic model (A vs. G, OR = 1.30, 95% CI 1.04–1.62, P = 0.02, FDR = 0.05) and dominant model (AA+AG vs. GG, OR = 1.25, 95% CI 1.04–1.51, P = 0.02, FDR = 0.05). However, rs1022563, rs1997794 and rs2235749 polymorphisms did not appear to associate with OD susceptibility.ConclusionsThere existed a significant association between rs1022563 polymorphism and OD among Asian population. As the included studies were not adequate to guarantee a robust and convincing conclusion, future studies with larger sample size among more ethnicities are recommended.
Highlights
Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility
Inclusion and exclusion criteria Publications that were included in the present study had to satisfy the following criteria: (1) case-control studies looking into the association of PDYN gene polymorphisms and OD; (2) case participants with confirmed diagnosis of OD; (3) studies with sufficient genotype counts to estimate odds ratio (OR) as well as 95% confidence interval (95%Confidence interval (CIs))
Literature search An initial search of four databanks yielded 151 records, of which 44 from Web of Science, 78 from EMBASE, 21 from PubMed, and 8 from Wanfang
Summary
Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility. A range of environmental factors like severe stressors, family separation, divorce, as well as death in the family have been considered to be associated with OD for a long time [2]. Early in 1990s, the isolation of genes that encoded opioid peptide precursors had opened an era of molecular and genetic investigations of OD [4]. Familybased studies in different countries and regions revealed the heritability estimates for substance dependence of twins ranged from 30 to 70% [5]. Numerous genes and single-nucleotide polymorphisms have been reported to be contributors of OD [6, 7]
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