Association between Primary Amenorrhea and Early Maternal Age: A Population Study

Abstract

Primary Amenorrhea (PA) is one of the most common reproductive disorders found in women can be characterized by the absence of menstruation cycle during puberty as well as throughout life that lead to infertility. The major cause of PA includes hypothalamic disorder and ovarian disorder. In this study a promising association between early maternal age and PA is found. This present study was carried out to perceive the effect of early maternal age (age of conception) in the etiology of PA. A population based study of approximately 993 PA cases and 1027 controls have been investigated in our laboratory (from 2004 and 2013). PA cases born to mothers of age less than 20 years are 71.70% and the mean age of mother is 16.15 years. A highly significant association of primary amenorrhea patient with the younger mother (≤ 20 years age) (OR = 5.51; 95% CI = 4.47- 6.79; p < 0.0001) has been found. On the other hand, association with older women is not significant (≥ 30 years) (OR = 1.17; 95% CI = 0.86-1.61; p < 0.315). Unpaired t-test analysis has shown statistical significant impact of younger maternal age on PA occurrence. The partial correlation of coefficient between maternal age and PA occurrence while keeping paternal age constant is 0.593. Statistical assessment shows a significant association between younger mother and daughter facing primary amenorrhea at puberty. There are different causes of PA which have been revealedbut the allianceof early maternal age with PA may be highlighted as the etiology of PA.