Abstract
Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066–1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the “GC” haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population.
Highlights
Coronary heart disease (CHD) is a major cause of death and disability worldwide [1]
For single nucleotide polymorphism (SNP) rs1759752, the allele frequency distributions differed between male cases and controls. (p = 0.015, Odds ratios (OR): 1.401, 95%confidence intervals (CIs): 1.066-1.481), whereas there was no significant difference in the female subgroup
For SNP rs1759752, the genotype frequency distributions differed between the male cases and controls (p = 0.019), while for rs12566304, the genotype frequency distributions differed between female cases and controls (p = 0.020) (Table 3)
Summary
Coronary heart disease (CHD) is a major cause of death and disability worldwide [1]. The incidence of CHD is higher in males than females. In China, the prevalence of CHD is increasing. One large study from the U.S puts the annual mortality rate due to CHD there at 5% among males and 3.65% among females [2]. CHD is characterized by remodeling and narrowing of the coronary arteries, which supply blood, and oxygen, to the heart [3]. Twins study has shown that heritable factors account for 30-60% of interindividual variation in the risk of CHD [4], which means genetic factors are key to an individual’s susceptibility to CHD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
