Abstract
ObjectivePolymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population.MethodsWe included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP).ResultsA substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0.001). In addition, substantially high frequencies of the GGCA and GGCG haplotypes were observed in the AR patients, unlike that observed in the control individuals (P<0.05). The results suggest that the AGTG haplotype may provide protection against AR (P<0.001).ConclusionsTo the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.
Highlights
In the past few decades, the prevalence of allergic diseases, including asthma, rhinitis, eczema, and food allergies, has risen sharply [1]
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in interleukin-23 receptor (IL-23R) and Allergic rhinitis (AR) in the Chinese Han population
Further investigation was performed to determine whether any association existed between the IL-23R single nucleotide polymorphisms (SNPs) and certain allergens of AR, such as seasonal grass pollens, house dust mites, dog and cat fur, molds, and cockroach
Summary
In the past few decades, the prevalence of allergic diseases, including asthma, rhinitis, eczema, and food allergies, has risen sharply [1]. Allergic rhinitis (AR), which is a condition similar to common cold, could affect mental and learning capacities up to 30% (Global Allergy and Asthma European Network addresses the allergy and asthma epidemic) [2].In 4 major cities in western China, the prevalence of self-reported AR was 32.30%(Chongqing), 34.3%(Chengdu), 37.9%(Urumqi), and 30.3%(Nanning) [3]. AR is a complex phenotype produced by the interaction of genes and the environment. It has been reported that numerous loci and candidate genes show an association with AR [4,5,6,7,8]. The molecular mechanisms underlying the development of AR have not been completely determined
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