Association between polymorphisms of OGG1, EPHA2 and age-related cataract risk: a meta-analysis.

Hongxu Zhang,Zhenyu Bian,You Peng,Jianguang Zhong,Xiang Fang,Yongping Hu

doi:10.1186/s12886-016-0341-y

Hongxu Zhang, Zhenyu Bian + Show 4 more

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https://doi.org/10.1186/s12886-016-0341-y

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Journal: BMC ophthalmology	Publication Date: Sep 29, 2016
Citations: 58	License type: cc-by

Affiliation: Hangzhou First People's Hospital

Abstract

BackgroundEvidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility.MethodsEligible case–control studies published between January 2000 and 2015 were searched and retrieved in the electronic databases. The odds ratio with 95 % confidence interval (CI) was employed to calculate the strength of the relationship.ResultsWe totally screened out six articles, including 5971 cataract patients and 4189 matched controls. Three variants were contained (OGG1 rs1052133; EPHA2 rs7543472 and rs11260867). For OGG1 rs1052133, we detected a significant correlation between OGG1 polymorphism and ARC risk under the heterogenous model (CG vs. CC: OR = 1.34, 95 % CI = 1.06–1.70, P = 0.01) and dominant model (GG+CG vs. CC: OR = 1.45, 95 % CI = 1.16–1.81, P = 0.001), especially in patients with cortical cataract of subgroup analysis by phenotypes (P < 0.05). For EPHA2 rs7543472 and rs11260867, we did not find a positive association between these two mutations and ARC susceptibility in total cases. Subgroup analysis by phenotypes of cataract showed that only in cortical cataract, genotypes of rs7543472 under the allele model, homogenous model and recessive model; genotypes of rs11260867 under the heterogenous model and dominant model were associated with ARC risk.ConclusionsOGG1 rs1052133 (CG and CG+GG genotypes) might be risk factor for ARC, particularly in cortical cataract risk. EPHA2 rs7543472 (T allele and TT genotype) and rs11260867 (CG and GG+CG genotypes) might be associated with cortical cataract.

Highlights

Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and ephreceptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk
All these articles were written in English, and genetic polymorphisms of OGG1 and EPHA2 were measured by polymerase chain reaction
This significant relationship was not found in EPHA2 polymorphisms, subgroup analysis by phenotypes of cataract showed that only in cortical cataract, the genotypes of rs7543472 under the allele model, homogenous model and recessive model; genotypes of rs11260867 under the heterogenous model and dominant model were associated with ARC risk

Summary

Introduction

Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and ephreceptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. According to the Global estimates of visual impairment, approximate 51 % of blindness and 33 % of visual impairment were estimated due to cataract between 2000 and 2010 [2]. There are racial/ethnic disparities in the prevalence of cataract [3]: Cataract of Europeans accounts for 50 % (WHO criteria) to 65 % (US criteria) of unilateral visual impairment, and 45 % (US criteria) of 5-year incident bilateral visual impairment [4]; Asian populations had a higher prevalence and earlier age of onset of cataract than Europeans [5]; while the prevalence of cataract was lower in Africans compared with Europeans [6]. 80 % of cataract is agerelated cataract (ARC) [9]. Based on the location of the opacity in the lens, ARC is classified as cortical cataract, nuclear cataract, or posterior subcapsular

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