Abstract
BackgroundColorectal cancer is the third most common cancer worldwide. Recently, an increasing number of evidences suggest that genetic susceptibility plays an important role in the occurrence of colorectal cancer. This study aimed to better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population.MethodsWe recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Genotyping was performed with the Agena MassARRAY platform. We used the χ 2 test to compare the distributions of single nucleotide polymorphisms (SNPs) allele and genotypes frequencies between cases and controls. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate the association under genetic models. Linkage disequilibrium between the five SNPs was assessed using the Haploview software.ResultsOverall analysis found that rs7336610 and rs1428 and haplotype CTAGA were significantly associated with increased risk of colorectal cancer. However, we found rs7318578 was associated with a decreased risk of colorectal cancer in the dominant model. Stratification analysis showed that rs7336610, rs7318578, and rs1428 were also associated with rectal cancer risk. Gender stratification analysis found that rs7336610, rs7318578, rs17735387, and rs1428 were significantly associated with colorectal cancer risk in males.ConclusionIn conclusion, this study indicated that the polymorphisms of MIR17HG were associated with colorectal cancer risk. Therefore, our findings may provide new insights into the development of colorectal cancer. Further association and functional studies are of great importance to confirm these results and to define the potential biological mechanism of colorectal cancer.
Highlights
Colorectal cancer is the third most common cancer worldwide and a major causes of cancer related morbidity and mortality (Bray et al, 2018)
The results revealed that individuals carrying the allele T of rs7336610 and allele A of rs1428 were associated with significantly increased risk of colorectal cancer (OR = 1.27, 95% confidence intervals (CIs): 1.07–1.51; odds ratios (ORs) = 1.27, 95% CI: 1.06– 1.51, respectively)
single nucleotide polymorphisms (SNPs): Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% Confidence interval OR and 95% CI were calculated using logistic regression adjusted with age and gender. p < 0.05 was considered statistically significant
Summary
Colorectal cancer is the third most common cancer worldwide and a major causes of cancer related morbidity and mortality (Bray et al, 2018). An increasing number of evidence suggests that genetic susceptibility plays an important role in the occurrence of colorectal cancer (Duan et al, 2014; Su et al, 2015; Wang et al, 2015; Zhang, Li, Du, et al, 2014b). Functional studies have confirmed the pivotal role of members of the MIR17HG in the development, progression, and aggressiveness of colorectal cancer (Ma et al, 2016; Tsuchida et al, 2011; Zhang, Li, Zhou, et al, 2014a). Few association studies on polymorphisms of MIR17HG and colorectal cancer risk has been reported (Sun et al, 2017). To better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population. We recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms (rs72640334, rs7336610, rs7318578, rs17735387, and rs1428) of MIR17HG and risk of colorectal cancer in the Chinese Han population
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