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Abstract
BackgroundMannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB.MethodsThe PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships.ResultsThere were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891.ConclusionsOur current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.
Highlights
Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk
The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019, using the keywords “tuberculosis,” “TB,” “polymorphism
The full texts of 53 articles were evaluated, and 23 additional articles were excluded because they contained duplicate data (4), they were meta-analyses/systematic reviews (10), they examined polymorphisms in other genes (2), or they were not case-control studies (7)
Summary
Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. Many studies have focused on the genetic variations within genes that †. Previous case-control association studies have revealed that several human genes might be correlated with TB in certain populations
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