Association between polymorphisms in ERCC2 gene and oral cancer risk: evidence from a meta-analysis

Enjiao Zhang,Xuexin Tan,Weiyi Duan,Zhongfei Xu,Shaohui Huang,Changfu Sun,Li Lu,Zhigang Cui,Zhihua Yin

doi:10.1186/1471-2407-13-594

Abstract

BackgroundExcision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERCC2 rs1799793 and rs13181 polymorphisms with oral cancer risks.MethodsWe retrieved the relevant articles from PubMed and Embase databases. Studies were selected using specific criteria. ORs and 95% CIs were calculated to assess the association. All analyses were performed using the Stata software.ResultsSix studies were included in this meta-analysis. There were no significant associations between ERCC2 rs1799793 and rs13181 polymorphism with overall oral cancer risk. In the stratified analysis by ethnicity, no significant associations were found. In the stratified analysis by tumor type, the risk of oral leukoplakia was significant associated with rs13181 polymorphism (AC vs. AA: OR = 1.28, 95% CI = 1.01-1.62, P = 0.546 for heterogeneity, I2 = 0.0%; CC vs. AA: OR = 1.94, 95% CI = 0.99-3.79, P = 0.057 for heterogeneity, I2 = 60.1%; dominant model AC + CC vs. AA: OR = 1.35, 95% CI = 1.08–1.69, P = 0.303 for heterogeneity, I2 = 17.6%; allele C vs. A: OR = 1.38, 95% CI = 1.04–1.82. P = 0.043 for heterogeneity, I2 = 56.4%).ConclusionRs13181 in ERCC2 gene might be associated with oral leukoplakia risk.

Highlights

Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts
Among three studies of ERCC2 rs1799793 polymorphisms, one study included the association between this polymorphism with oral cancer risk and all of the three studies contain the association between the polymorphism and oral leukoplakia risk
In the stratified analysis by tumor type, the risk of oral leukoplakia was significant associated with rs13181 polymorphism

Summary

Introduction

Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. The various DNA repair pathways play important roles in the genomic stability, defending against carcinogenesis. There has been increasing evidence that DNA damage plays a critical role in the carcinogenesis of most cancers and DNA repair genes are considered key genes associated with the onset of cancer [6,7,8]. Tobacco-induced DNA adducts are primarily removed by nucleotide excision repair (NER) pathway. The variation in DNA repair capacity may due to the single nucleotide polymorphisms (SNP) in DNA repair genes. It is of utmost importance to investigate the SNPs in genes involved in NER pathway to understand the etiology of oral cancer

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Results

Conclusion