Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands

Abstract

IntroductionCertain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain). Patients and methodsPolymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR] <30ml/min/1.73m2) secondary to T2DM, 110 patients with T2DM onset ≥20 years before without advanced CKD (eGFR ≥45ml/min/1.73m2 and no proteinuria), and 292 healthy blood donors over 50 years of age without CKD or diabetes. ResultsThe frequency of the risk allele for rs2032487 was 10.7% in patients with diabetes and advanced CKD, 7.1% in those with diabetes but without advanced CKD, and 6.1% in healthy subjects, with significant differences between the first and third groups (p=0.015). Among subjects with advanced CKD, 78.5% were homozygous for the protective allele, as compared to 87.9% in the other two groups (p=0.015 and p=0.016 respectively). The frequency of the risk allele for the rs73885319 polymorphism did not exceed 0.5% in any of the three groups. ConclusionsThese data suggest that polymorphism rs2032487 is associated to advanced CKD related to T2DM in the population of Gran Canaria.