Association between polymorphism of NOD-1 and susceptibility of Guillain-Barre syndrome in children

Abstract

Objective To investigate the genetic association between NOD-1 gene polymorphism and susceptibility to children Guillain-Barre Syndrome (GBS) in the Han descent population in Shaanxi province. Methods During January 2013 to October 2016, 112 children with GBS were recruited to participate in the study as the GBS group; 110 healthy volunteers without GBS were randomly selected in the same period of time as the control group. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for detection of the polymorphism of the NOD-1 gene. Results Rs2075820 gene polymorphism exhibited strong correlation with children GBS in dominant model, recessive genetic model and allele model (P=0.013; P=0.016; P=0.005). In GBS subgroups, there was significant association between rs2075820 gene polymorphism and acute inflammatory demyelinating polyneuropathy (AIDP) in dominant and allele model (P=0.018; P=0.015). Meanwhile, a significant association was found between rs2075820 gene polymorphism and acute motor axonal neuropathy (AMAN) in dominant model, recessive genetic model and allele model (P=0.024; P=0.004; P=0.002). No statistically significant correlation was found between rs2075820 gene polymorphism and acute motor-sensory axonal neuropathy (AMSAN) in any of these models. Rs7789045 gene polymorphism showed no statistically significant correlation with GBS and its subtypes in any model. For children with GBS, polymorphism of NOD-1 was not related to disease severity and prognosis. Conclusion Polymorphism of the NOD-1 (rs2075820) gene was associated with the susceptibility of GBS. Key words: Guillain-Barre Syndrome; NOD-1; Gene Polymorphism; Children