Association between polymorphism of MMP-1 promoter and the susceptibility to anterior disc displacement and temporomandibular joint osteoarthritis

Abstract

ObjectiveTo investigate the correlation of the polymorphism of MMP-1 promoter (−1607 1G/2G) with the susceptibility to anterior disc displacement (ADD) and temporomandibular joint osteoarthritis (TMJ OA). MethodsA total of 185 healthy individuals (group A), 141 unilateral ADDWR patients (group B), and 321 unilateral ADDWOR patients (group C) were included in the investigation. Group C included 115 patients without TMJ OA (named group C-1) and 206 with TMJ OA (named group C-2). The genotyping of this single nucleotide polymorphism was evaluated by high resolution melting assay. Pairwise comparison between the distributions of genotypes and alleles in these groups was conducted with a multivariate logistic regression model adjusted on the basis of possible covariates. ResultsA significant difference in the 2G2G genotype frequency was found among the different groups on the basis of three sets of comparisons (PC-A<0.0005; PC1-B=0.049; PC2-B=0.018). The susceptibility of 2G2G genotype carriers to ADDWOR with or without TMJ OA was considerably higher than that of other genotypes carriers (ORC-A=2.455; ORC1-B=1.849; ORC2-B=1.912). A significant difference in 1G2G genotype frequency was also observed on the basis of two sets of comparisons (PC-A<0.0005; PC2-B=0.041). The susceptibility of 1G2G genotype carriers to ADDWOR with or without TMJ OA was also considerably higher than that of other genotype carriers (ORC-A=2.641; ORC2-B=1.896). ConclusionThe −1607 1G/2G polymorphism of MMP-1 promoter may be related to the susceptibility to ADDWOR with or without TMJ OA.