Association Between PM2.5 Exposure and the Prognosis of Patients with Acute Myocardial Infraction

Abstract

Numerous case-crossover and time series studies of PM2.5 exposure and cardiovascular health effects have been conducted, fever studies have examined the effects of PM2.5 on the outcomes of CHD, especially on acute myocardial infarction (AMI). The objective of this research is to investigate the association between PM2.5 exposure in Tianjin City and the outcome of AMI. We conducted a retrospective analysis of a total of 598 patients with AMI in TEDA International Cardiovascular Hospital, from Oct 28th, 2013-Apr 30th 2014. All patients were divided into five groups according to the National Air Quality Classification Standard. Major adverse cardiovascular events (MACEs) including all-cause death, heart failure, myocardial infarction and target lesion revascularization (TLR) during one year follow-up were defined as endpoint. Furthermore, we divided the patients into two groups according to better and worse air quality, then examined the incidence of MACEs in the two groups. The prognostic was assessed by using multivariate Cox regression analysis. With the increase of the concentration of PM2.5, the incidence of MACEs were higher in patients after 1year of AMI (In the five groups, Hazard Ratio [HR] 1.622, 95% CI 1.352-1.947; p=0.000. In the two groups, HR 3.255, 95% CI 2.008-5.276; p=0.000). PM2.5 exposure was associated with the outcome of patients with AMI, especially, the poorer air quality it is, the worse prognosis of patients will be.