Abstract
Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the association between PLCE1 rs2274223 polymorphism and cancer risk, but the conclusions are inconclusive. To obtain a comprehensive conclusion, we performed a meta-analysis of 22 studies with 13188 cases and 14666 controls. The pooled results indicated that PLCE1 rs2274223 A > G polymorphism was associated with an increased risk of overall cancer (G vs. A: OR = 1.15, 95% CI = 1.06–1.25; GG vs. AA: OR = 1.30, 95% CI = 1.10–1.55; GA vs. AA: OR = 1.18, 95% CI = 1.08–1.30; GG/GA vs. AA: OR = 1.20, 95% CI = 1.08–1.32; GG vs. GA/AA: OR = 1.22, 95% CI = 1.04–1.42). The stratification analysis showed the polymorphism was significantly associated with an increased risk of esophageal squamous cell carcinoma (ESCC) other than gastric cancer (GC), especially among the subgroups of Asian, high quality score, sample size > 1000 and the studies consistent with Hardy-Weinberg equilibrium (HWE). This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC. However, due to the substantial heterogeneities across the studies, the conclusion might be not conclusive that need more studies to confirm.
Highlights
Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis
In 2010, Abnet et al firstly performed a genome-wide association studies (GWASs) of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in Chinese populations and identified variants located in the PLCE1 gene at chromosome 10q23 had a genome-wide significantly correlation with gastric cardia cancer (GCA) and ESCC5
Among the 22 studies, six studies reported on GC with 6813 cases and 5666 controls, and nine studies reported on ESCC with 3348 cases and 5309 controls
Summary
Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the association between PLCE1 rs2274223 polymorphism and cancer risk, but the conclusions are inconclusive. The stratification analysis showed the polymorphism was significantly associated with an increased risk of esophageal squamous cell carcinoma (ESCC) other than gastric cancer (GC), especially among the subgroups of Asian, high quality score, sample size . Wu et al further confirmed seven single nucleotide polymorphisms (SNPs) at five regions significantly associated with ESCC, among which is PLCE1 rs2274223 that has been found in the former two GWASs7.
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