Association between platelets and in-hospital mortality in critically ill patients with tumors: A retrospective cohort study.

Abstract

e18552 Background: Platelet count is an independent predictor of mortality in cancer patients. It remains unknown whether the platelet count is related to in-hospital mortality in severely ill patients with tumours. Methods: A retrospective study based on a dataset from a multicentre cohort. Setting This was a secondary analysis of data from one Electronic Intensive Care Unit (eICU) Collaborative Research Database (eICU- CRD) survey cycle (2014-2015). Participants The data pertaining to severely ill patients with tumours were collected from 208 hospitals located across the United States. This study initially a total of 200859 participants. After the population was limited to patients with combined tumours and platelet deficiencies, the remaining 2628 people were included in the final data analysis. Primary and secondary outcome measures The main measure was the platelet count, and the main outcome was in-hospital mortality. Results: After adjustment for the covariates, the platelet count had a curvilinear relationship with in-hospital mortality (P < 0.001). The first inflection point was 18.4 (per 10 change). On the left side of the first inflection point (platelet count ≤ 184 K/mcL), an increase of 10 in the platelet count was negatively associated with in-hospital mortality [OR = 0.92, 95% CI = 0.89 to 0.95, P < 0.001]. The second inflection point was 44.5 (per 10 change). Additional increases of 10 in the platelet count thereafter were positively associated with hospital mortality [OR = 1.13, 95% CI = 1.00 to 1.28, P = 0.0454]. The baseline platelet count was in the range of 184 K/mcL to 445 K/mcL(P = 0.0525), and the hospital mortality was lower than the baseline platelet count in other ranges. Conclusions: The relationship between platelet count and in-hospital mortality in critically ill patients with tumours was curvilinear. The lowest in-hospital mortality was associated with platelet count between 184 K/mcL and 445 K/mcL. This indicates that both high and low platelet count should receive attention in clinical practice.