Association between plasma fibroblast growth factor 21 and related factors levels in newly diagnosed type 2 diabetes mellitus patient

Abstract

Objective To investigate the relationship between plasma fibroblast growth factor 21 (FGF-21) levels and body mass index(BMI), plasma glucose, plasma insulin levels, as well as other factors in newly diagnosed type 2 diabetes mellitus (T2DM). Methods 180 subjects who visited Department of endocrinology, Chaoyang Hospital, Capital Medical University from January to July in 2013 were enrolledand divided into newly diagnosed T2DM group (DM group, n=136) and Impaired glucose tolerance (IGR group, n=44). We selected 52 healthy volunteer as control group (NCM group). Plasma FGF-21 levels were determined by ELISA. The association between plasma FGF-21 levels and BMI, plasma glucose, blood lipids, plasma insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of insulin sensitivity index(HOMA-ISI) and other factors were also analyzed. We use independent-samples t test, Pearson's correlations, multivariate linear regression analysis. Results Plasma FGF-21 levels in newly diagnosed T2DM patients were significantly higher than those of healthy individuals (319.2±2.5 vs 223.09±1.43, t=2.804, P<0.05). Plasma FGF-21 levels positively correlated with triglyceride (TG) in newly diagnosed T2DM patients and healthy individuals (r=0.26, 0.38, respectively, P< 0.05 all above). Plasma FGF-21 levels positively correlated with BMI in IGR group (r=0.33, P<0.05). Multiple regression analysis suggested that HOMA-ISI was an independent related factor influencing plasma FGF-21 levels. Conclusion FGF-21 in newly diagnosed T2DM patients is associated with triglyceride levels, insulin resistance. Key words: Diabetes mellitus, type 2; Insulin resistance; Fibroblast growth factor 21