Abstract
Background: An understanding of atrial fibrillation (AF) mechanisms, as the most common cardiac arrhythmia, is essential for primary and secondary prevention. Some studies indicated an association between microalbuminuria and C-reactive protein (CRP) protein, with the incidence and prevalence of AF. This study aimed to investigate the relationship between permanent non-valvular AF with microalbuminuria and reactive protein C. Materials and Methods: In this case-control study, 40 permanent non-valvular AF patients and 40 non-AF patients (control group) were studied. Demographic data and measurements of albumin, urine creatinine, CRP, and microalbuminuria were recorded and compared between the two groups. Results: In patients with permanent non-valvular atrial fibrillation, CRP level (P<0.001) and microalbuminuria (P=0.012) were significantly higher than the control group. Also, in patients with permanent non-valvular AF, the CRP positive (P = 0.014) and microalbuminuria (P = 0.003) were significantly higher than controls. The results showed that elevated chance of permanent non-valvular AF with abnormal CRP was 4.25 (odds ratio [OR]= 4.25, 95% confidence interval [CI]: 1.18-1.28; P= 0.026), and with microalbuminuria was 6.54 (OR= 6.54, 95% CI: 1.65-25.89; P=0.007). Conclusion: An elevated CRP level and microalbuminuria were significantly associated with permanent non-valvular atrial fibrillation. A longitudinal study is necessary. [GMJ.2021;10:e2106]
Highlights
Atrial fibrillation (AF) is one of the permanent disorders of heart rhythm that is associated with several problems in the individual [1]
The relationship between microalbuminuria and atrial fibrillation (AF) has been studied in some research, and the results show that microalbuminuria, as an independent factor, could predict the prevalence of AF [11]
Patients with microalbuminuria distorters, macroalbuminuria, intake medication during the last six months, systemic diseases, serum creatinine higher than 20 mg/L, hematuria, pregnancy, acute urinary tract infection, acute fever greater than 38 °C, diabetes, intense exercise in the last 24 hours, receiving radiocontrast, C-reactive protein (CRP) level disrupting conditions, leukemia, hormone therapy, recent surgery, malignant tumors, weight loss, and moderate alcohol consumption [8, 15] were excluded from the study
Summary
Atrial fibrillation (AF) is one of the permanent disorders of heart rhythm that is associated with several problems in the individual [1]. Microalbuminuria is defined as the excretion of albumin at a rate of 30 to 300 mg/dL in 24hour urine, which could be used as an indicator of damage or endothelial dysfunction of all arteries in the body, including ischemic heart disease, diastolic heart failure, and congestive heart failure [8] This criterion could be an independent risk factor for inducing heart diseases, such as atherosclerosis [9,10]. Results: In patients with permanent non-valvular atrial fibrillation, CRP level (P
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