ASSOCIATION BETWEEN PERIRENAL ADIPOSE TISSUE, METABOLIC PARAMETERS AND BLOOD PRESSURE PROFILE IN PATIENTS WITH ABDOMINAL OBESITY

Abstract

Objective: Perirenal adipose tissue is considered as new marker of cardiometabolic risk, as particular visceral fat depot, can leads to metabolic decoders and organ damage. The aim of study to assess the effects of perirenal adipose tissue on metabolic parameters and 24-hours profile of blood pressure in patients with abdominal obesity. Design and method: The study included 104 patients (37,5% - men, 62.5% - women), mean age 38.59 ± 6.09 years with abdominal obesity (waist circumference (WC) > 80 cm in women and > 94 cm in men), without cardiovascular diseases and diabetes mellitus. Perirenal adipose tissue (PAT) volume was measured by multislice computed tomography (MSCT) (ToshibaAquillion 640, Japan). Blood sampling and measurements of lipid levels, fasting glucose, insulin, HOMA index, 24-hour ambulatory blood pressure monitoring were performed. Results: PAT volume was associated with WC (r = 0,70; p < 0,05) in participants with abdominal obesity. A positive correlation was found between PAT and triglyceride (r = 0,35; p < 0,05), insulin (r = 0,37; p < 0,05), HOMA-index (r = 0,38; p < 0,05); creatinine (r = 0,30; p < 0,05) and a negative correlation - with HDL-cholesterol (r = -0,40; p < 0,05). There was no association between PAT and LDL-cholesterol. PAT was associated with day (r = 0,29; p < 0,05) and night (r = 0,39; p < 0,05) systolic blood pressure and with day (r = 0,30; p < 0,05) and night (r = 0,30; p < 0,05) systolic blood pressure. Conclusions: PAT is associated with metabolic disorders, insulin resistant index and blood pressure profile in patients with abdominal obesity.