Abstract
To investigate the independent association between peripheral leukocyte telomere length and dietary vitamin A and carotenoid, we collected 839 participants older than 20-year from the 1999-2000 National Health and Nutrition Examination Survey. The peripheral leukocyte telomere length was obtained using the quantitative polymerase chain reaction method. Dietary information, such as alcohol, caffeine, carotenoid, folate and vitamin A/B1/B2/B6/B12/C/E was from a recall of the previous 24h taken food. Multivariable logistic regression and smooth curve fitting was conducted to analyze the independent association between telomere length and dietary vitamin A and carotenoid. Obesity was further treated as effect modification factor in the stratified analysis. After adjusting for age, race, sex, education, obesity, physical activity, PIR, smoking status, CAD history, serum concentrations of vitamin E/A/B12, folate, gamma-tocopherol, CRP, total cholesterol, cadmium and dietary intake of alcohol, caffeine, fiber, folate and vitamin B1/B2/B6/B12/C/E, the daily vitamin A and carotenoid intake was not significantly associated with telomere length in general population (vitamin A: 0.0009, 95% CI: -0.0041, 0.0058; carotenoid: 0.0040, 95% CI: -0.0458, 0.0538). In non-obesity population, the association coefficient was -0.0121 (95% CI: -0.0259, 0.0017) for vitamin A and -0.1369 (95% CI: -0.2809, 0.0070) for carotenoid. Vitamin A and carotenoid consumption was not associated with peripheral leukocyte telomere length independently in general adult population. However, in non-obese individuals, increasing vitamin A and carotenoid might tend to associate with decreasing peripheral leukocyte telomere length.
Highlights
Locating at both ends of chromosomes, telomere contains a repetitive sequence of 5’-TTAGGGn-3’ serving to protect chromosome stability and integrity, adjust cellular proliferation, and prevent chromosome end fusions [1,2]
We aimed to address the association between the peripheral leukocyte telomere length and dietary vitamin A as well as carotenoid, according to the 1999-2000 National Health and Nutrition Examination Survey (NHANES) in United States adult population
Significant difference was not found in mean peripheral leukocyte telomere length (P= 0.82) among males and females
Summary
Locating at both ends of chromosomes, telomere contains a repetitive sequence of 5’-TTAGGGn-3’ serving to protect chromosome stability and integrity, adjust cellular proliferation, and prevent chromosome end fusions [1,2]. Telomere length has become one of biological aging markers to monitor chronic diseases risks [5,6,7,8] and potential death risk [8,9,10]. Diet can affect the telomere length [18,19,20]. Some nutrients can increase the telomere length, while others may shorten it. Fruit and vegetable intake were suggested positively associated with telomere length [19,20,22,23,24]. The processed meat, sweetened carbonated beverage and sugar-sweetened soda intake might shorten telomere length [19,25,26]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
