Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases

Abstract

Objective To investigate the correlation between peripheral blood levels of 25-hydroxyvitamin D [25(OH)D] and hypersensitive C-reactive protein (hs-CRP) in patients with inflammatory and non-inflammatory diseases. Methods A total of 281 patients (130 patients with inflammatory disease and 151 cases with non-inflammatory disease) were involved in this study between September 2017 and November 2017. The levels of 25(OH)D and hs-CRP in peripheral blood were detected by electrochemiluminescence and turbidimetry, respectively. Results The levels of 25(OH)D in the inflammatory disease group were significantly negatively correlated with those of hs-CRP (r=-0.780, P<0.001). In the non-inflammatory disease group, the 25(OH)D levels and hs-CRP concentrations had a weaker negative association (r=-0.636, P<0.001). Conclusion Peripheral blood levels of 25(OH)D are negatively associated with hs-CRP not only in patients with inflammatory disease but also in non-inflammatory populations. The correlation in the inflammatory group is significantly higher than that in the non-inflammatory group. Key words: High-sensitivity; 25-hydroxy vitamin D; Inflammatory disease; Inflammatory