Abstract
Asthma and periodontitis are both very prevalent worldwide. Although the association between these diseases has been investigated, the biological mechanism underlying this association, especially the role of biological mediators, remains unclear. Thus, the aim of this study was to evaluate serum levels of anti-Porphyromonas gingivalis IgG in subjects with and without severe asthma. A case-control study involving 169 individuals consisted of subjects with severe asthma in addition to others without asthma (control group). An indirect enzyme linked immunosorbent assay (ELISA) was performed to measure serum levels of IgG specific to Porphyromonas gingivalis. Bacterial DNA was extracted from subgingival biofilm samples and real-time polymerase chain reaction (RT-PCR) analysis was performed to quantify Porphyromonas gingivalis levels.
Highlights
Campus Universitário Abstract- Asthma and periodontitis are both very prevalent worldwide
169 individuals consisted of subjects with severe asthma in Asthma, an inflammatory disease affecting the addition to others without asthma
Bacterial DNA was extracted from subgingival biofilm samples and real-time polymerase chain reaction
Summary
Porphyromonas gingivalis in their biofilm than individuals without periodontitis (p=0.001). Is important to emphasize that these studies did not include individuals diagnosed with any other diseases, nor those taking medications, such as corticosteroids, which like this eliminated agents capable of modulating host response Given this fact, it is possible to speculate that, in individuals with chronic periodontitis, the presence of severe asthma may modulate the production of IgG specific to Porphyromonas gingivalis, which reinforces the bidirectional association between these two diseases. In light of its limitations, the present study seems to suggest that the occurrence of severe asthma is capable of modulating the colonization of Porphyromonas gingivalis in the subgingival biofilm, in addition to the production of IgG specific to antigens of this bacterium (extract and HmuY) in the sera of individuals with periodontitis
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