Abstract
Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in women. It is believed that sex hormones play a role in the maintenance of bone mass and directly or indirectly influence several cell types, including periodontal cells. Objective: To evaluate the association between periodontal disease and PCOS according to the evidence reported in the last decade. Material and Method: A search was made in the biomedical databases: Pubmed, Embase, Scopus, SciELO, Science Direct and SIGLE for the 2007-2017 period. Selection criteria: prospective and retrospective studies reporting the relationship between periodontal disease and PCOS. The methodological quality of the studies was analyzed using the Critical Appraisal Skills Program scale. Results: 10 articles were found: 1 clinical trial and 9 case-control studies. The number of patients ranged from 48 to 196, mean age between 23.3 and 28.1 years, age range between 15 and 45 years. Studies were conducted in Turkey, India and Iran. All the studies presented good methodological quality and a positive association between PCOS and periodontal disease. Conclusion: PCOS shows a positive and significant association with the clinical and molecular parameters of periodontal diseases.
Highlights
IntroductionPolycystic ovary syndrome (PCOS) is one of the multiple conditions that affect women, and one of the most frequent endocrine disorders.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17] It is characterized by menstrual abnormalities, hyperandrogenism, polycystic ovary and increased risk of developing metabolic and cardiovascular diseases.[2,3,5,6,7,8,9,10,11,12,13,14,15,16,17,18] PCOS is likewise the main cause of infertility,[5,10,11,16,18] and is reciprocally associated with oral health.[11,17] Periodontal disease consists of a group of conditions that affect the protective (gingiva) and support tissues (periodontal ligament, root cement and alveolar bone) of the teeth
Serum levels of MMP-9 and MPO were higher in the PCOS and gingivitis (Pg) demonstrated by salivary and group compared to the Ph group (p
All the analyzed studies showed a positive association between Polycystic ovary syndrome (PCOS) and periodontal diseases
Summary
Polycystic ovary syndrome (PCOS) is one of the multiple conditions that affect women, and one of the most frequent endocrine disorders.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17] It is characterized by menstrual abnormalities, hyperandrogenism, polycystic ovary and increased risk of developing metabolic and cardiovascular diseases.[2,3,5,6,7,8,9,10,11,12,13,14,15,16,17,18] PCOS is likewise the main cause of infertility,[5,10,11,16,18] and is reciprocally associated with oral health.[11,17] Periodontal disease consists of a group of conditions that affect the protective (gingiva) and support tissues (periodontal ligament, root cement and alveolar bone) of the teeth. Conclusion: PCOS shows a positive and significant association with the clinical and molecular parameters of periodontal diseases
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