Abstract
Previous studies have suggested that peptic ulcer disease (PUD) including stomach and duodenal ulcers might be associated with periodontitis (PD); however, no clear conclusions have been reached thus far. In this retrospective case-control study, we aimed to investigate the association between PUD and PD by using a large population-based dataset in Taiwan. A population-based retrospective case control study was conducted using the Longitudinal Health Insurance Database 2010 (LHID2010) derived from the National Health Insurance Research database (NHIRD) in Taiwan from 2000 to 2013. The case and control group were matched with gender, age, urbanization level, socioeconomic status, and Charlson comorbidity index (CCI) by using the propensity score method at a 1:1 ratio. A total of 177,240 cases and 177,240 control patients were included in this study, with an average age of 46.96 11.76 years. The risk of PUD for patients diagnosed with PD was 1.15-fold when compared with those without PD (OR, 1.15; 95% CI, 1.12–1.18). This population-based case control study demonstrated a significantly positive association between PUD and PD in Taiwan.
Highlights
Peptic ulcer disease (PUD) is a disease located in the gastric or duodenal part of the gastrointestinal tract that mainly involves the mucosa layer
PUD: peptic ulcer disease; OR: odds ratio. In this case-control study, we revealed that PD was positively associated with PUD (OR, 1.15; 95% confidence intervals (CIs), 1.12–1.18)
The chronic inflammation is associated with multiple systemic diseases including diabetes mellitus [18], rheumatoid arthritis [19], and cardiovascular disease [20]
Summary
Peptic ulcer disease (PUD) is a disease located in the gastric or duodenal part of the gastrointestinal tract that mainly involves the mucosa layer. The two main risk factors for PUD are Helicobactor pylori (H. pylori) infection and medication consumption, especially of nonsteroid anti-inflammatory drugs (NSAIDs) [1]. The prevalence of PUD ranges from 0.12 to 1.5% and increases with age [2]. The major symptom of uncomplicated PUD is upper abdominal dyspepsia such as bloating, early satiety, and nausea [3]. Periodontitis (PD) is defined as an inflammatory disease of the supporting tissues surrounding the teeth [4]. Inflammatory periodontal disease results from a complex interaction between the subgingival biofilm and the host immune–inflammatory events [5]. In response to the challenge presented by the bacteria, progressive destruction in the gingival and periodontal tissues occurs
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