Association between pentraxin-3, body fat distribution and carotid intima media thickness in premenopausal obese women

Özen Dedeoğlu ,Duygu Herek ,Hande Şenol ,Güzin Fidan-Yaylalı ,Süleyman Demir ,Şenay Topsakal

doi:10.30918/irjmms.71.18.065

Abstract

Association between pentraxin-3, body fat distribution and carotid intima media thickness in premenopausal obese women

Highlights

Pentraxin-3 (PTX3) is an acute-phase protein, it has structural similarity with C-reactive protein (CRP)
We aimed to investigate the relationships between Pentraxin 3 (PTX3), CRP, body fat distribution and carotid intima media thickness (CIMT). 73 obese premenopousal women and 53 women with normal body mass index (BMI) took part in this study
CRP is significantly higher in obese patients (p < 0.01)

Summary

Introduction

Pentraxin-3 (PTX3) is an acute-phase protein, it has structural similarity with C-reactive protein (CRP). In response to inflammatory signals, the liver produces the classic short pentraxin CRP (Pepys and Hirschfield, 2003), which strongly associates with cardiometabolic disorders such as obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis (Ridker et al, 2000). PTX3 plasma levels rapidly rise in the early phase after ischemic heart disorders (Peri et al, 2000; Bonacina et al, 2013). Because different cells within adipose tissue might produce PTX3 (Abderrahim-Ferkoune et al, 2003), it could be a more sensitive marker of inflammation caused by obesity than CRP. The association between circulating levels of PTX3 and measures of adiposity is inconsistent. Some studies have found positive associations (Alberti et al, 2009; Miyaki et al, 2010), whereas other have demonstrated inverse associations (Osorio-Conles et al, 2011; Barazzoni et al, 2013; Miyaki et al, 2013; Miyamoto et al, 2011; Ogawa et al, 2010; Yamasaki et al, 2009; Witasp et al, 2014)

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