Abstract
Non-stimulated whole saliva samples were collected from a total of 84 pregnant women (including 29 during the first trimester, 29 in the second trimester, 26 at the end of pregnancy), 33 postpartum women, who were chosen randomly. The plaque index (PlI), sulcus bleeding index (SBI), periodontal probing depth (PPD) and attachment lost (AL) were recorded. Periodontal microorganisms including porphyromonas gingivalis (Pg), prevotella intermedia (Pi), prevotella nigrescens (Pn) were detected by using 16S rRNA based polymerase chain reaction (PCR) method.
Highlights
The aim of this study is to compare the detection of periodontal pathogens in the oral cavity of pregnant and non-pregnant women in the childbearing age and to understand the influence of pregnancy status on the ecology of periodontal pathogens
The high detection rate of Prevotella nigrescens (Pn) in pregnant women implied the effect of pregnant status on microbiota of oral cavity
Pn might be the dominant bacteria in the oral cavity of the pregnant women when compared with prevotella intermedia (Pi) and porphyromonas gingivalis (Pg)
Summary
The aim of this study is to compare the detection of periodontal pathogens in the oral cavity of pregnant and non-pregnant women in the childbearing age and to understand the influence of pregnancy status on the ecology of periodontal pathogens. Periodontal diseases are chronic infection caused by interactions between microorganisms and the immune system of chronic bacterial infection, environmental, behavioral, and/or genetic factors [1]. As an environmental factor, increases the response of gingival tissue to microbial plaque, which is prone to causing gingivitis during pregnancy. The increase in hormone activity during pregnancy aggregates the existed gingival chronic inflammation, so the gums bleed, swell, and even form tumor-like changes that affect the chewing, digestion and absorption of pregnant women [5,6]. Study by Offenbacher, et al has shown that pregnant patients with periodontitis have a high degree of inflam-
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