Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-Analysis Collaboration

Abstract

(JAMA. 2018;319(21):2190–2201) Oxygen saturation is almost universally measured by pulse oximetry (SpO2) in neonatal intensive care units. While a lower SpO2 target (≤90%) may reduce retinopathy of prematurity (ROP), it also may impair neurodevelopment or increase the risk of death. On the other hand, higher oxygen levels (SpO2 target >90%) may increase the risk of adverse pulmonary sequelae. In 2003, 5 investigators planning separate randomized prospective clinical trials using similar study designs agreed to provide data after completion for a meta-analysis. This article detailed the results of the meta-analysis.