Abstract
Background/Aim: Coronavirus 2019 (COVID-19) infection is caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has become an emergency condition for global public health. Oxygen saturation has important role for diagnosing the patient in the hospital. The neutrophil-lymphocyte ratio (NLR) is a marker for the viral inflammatory reaction to confirm the viral or bacterial infection. The D-dimer is also known as biomarker for severity and prognosis of COVID-19. The aim of the study was to investigate the risk factors of mortality in COVID-19 patients based on oxygen saturation, neutrophil-lymphocyte ratio and D-dimer. Methods: Data has been obtained from confirmed cases of COVID-19 in Abdul Wahab Sjahranie Hospital from October until November 2020. They were collected and analysed with Chi-squared test by SPSS 22.0 software. Results: There were 60 patients with SARS-CoV-2 infection in this study, 48 (80 %) patients survived and 12 (20 %) deceased. Peripheral oxygen saturation < 90 % had 13 (21.7 %) and ≥ 90 % had 47 (78.3 %) patients. There were 13 (21.7 %) patients with NLR value < 3.13 and ≥ 3.13 47 (78.3 %) patients. D-dimer value less than 0.5 had 9 (15 %) and ≥ 0.5 had 51 (85 %) patients. The results of statistical analysis have showed that there were relationship between oxygen saturation (p = 0.002) and survival rate of COVID patients. Conclusion: According to the research that has been conducted, there was correlation between oxygen saturation and mortality of COVID-19 patient. It could be used as biomarker to improve the management of COVID-19 patients.
Highlights
Coronavirus disease 2019 (COVID-19), was discovered in Wuhan, China, in December 2019
Background / Aim: Coronavirus 2019 (COVID-19) infection is caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)
The aim of the study was to investigate the risk factors of mortality in COVID-19 patients based on oxygen saturation, neutrophil-lymphocyte ratio and D-dimer
Summary
Coronavirus disease 2019 (COVID-19), was discovered in Wuhan, China, in December 2019. There are several clinical manifestations of this virus including fever, cough and shortness of breath, watery diarrhoea, myalgia, severe lymphopenia, prolonged clotting profiles, heart disease and sudden death.[6, 7] The incidence rate of coronavirus has increased greatly in various countries, so WHO has declared it as pandemic on 30 January 2020.8 Statistics has shown 14 % of pneumonia-related COVID-19 cases are severe and 5 % of infected patients require intensive care.[9] This situation is very high risk nationally as well as globally as long as vaccine implementation is still in progress. Based on the laboratory results, there are biomarkers that could represent inflammation mortality such as oxygen saturation, neutrophil lymphocyte ratio (NLR) and D-dimer
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