Abstract
BackgroundAlthough delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.MethodsOne-hundred mothers and their term neonates were included in the present study. Umbilical cord blood samples were collected from the umbilical vein and umbilical artery immediately following labor.ResultsTotal cholesterol, total triglycerides and phospholipids levels were significantly higher in the ECC group than the DCC group (p < 0.001 in all). Plasma total antioxidant status was higher in the DCC group than the ECC group (p < 0.001). While, plasma hydroperoxides were lower in the DCC group than the ECC group (p < 0.001). Levels of erythrocytes catalase cytosol, superoxide dismutase and glutathione peroxidase were significantly higher in the DCC group than the ECC group (p < 0.001).ConclusionDCC was associated with a decrease in cord blood lipids and an augmented antioxidant activity. This suggests the protective effect of DCC on the future health of the term neonates and supports the application of DCC in active management of 3rd stage of labor in term neonates.
Highlights
Delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries
We compared some clinical characteristics of the participated mothers and newborns in the delayed cord clamping (DCC) group versus those in the ECC group, such as maternal age, weight, parity, time of placental separation, presence of postpartum hemorrhage and neonatal weight
Regarding to the cord blood serum lipids, total cholesterol, total triglycerides, and phospholipids levels were significantly higher in the ECC group than in the DCC group in both umbilical artery and vein (p < 0.001 in all)
Summary
Delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. The umbilical cord was clamped early in the first 30 s of labor (early cord clamping), as part of active management of the 3rd stage of labor [2]. This is still widely practiced even in developed countries. As delayed clamping allows time for a transfer of the fetal blood in the placenta to the neonate at the time of labor. This placental transfusion can provide the neonate with an additional 30% more blood volume and up to
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