Association between oral health and cognitive frailty in community‐dwelling older adults

Abstract

AbstractBackgroundCognitive frailty indicates the presence of both physical frailty and mild cognitive impairment (MCI) and has been associated with an increased risk of adverse health outcomes (e.g., mortality). Poor oral health has been related to cognitive impairment and physical frailty, respectively. However, the association between oral health and cognitive frailty remains unclear. This study aimed to explore the association between oral health and cognitive frailty in community‐dwelling older adults.MethodThis 10‐year cohort study (2011‐2021) is a part of an ongoing prospective cohort study. At baseline (2011‐2013), 605 non‐demented community‐dwelling older adults (aged 65+) with four biennial follow‐ups. Cognitive frailty was defined as the coexistence of MCI and physical frailty. Extended definitions of cognitive frailty were also assessed and defined as the coexistence of impaired cognitive domains and physical frailty. Oral health variables included tooth defects, dentition, and periodontal status. The generalized linear mixed model was used to explore the longitudinal association between oral health and cognitive frailty, adjusting for age, sex, lifestyle, comorbidity, and so on.ResultThe mean age of the study participants was 72.7 at baseline, and 53.4% were female. We found that tooth defect was associated with worsening of impaired memory‐frailty [adjusted odds ratio (aOR) = 1.13; 95% confidence interval (CI) = 1.03‐1.24] and impaired verbal fluency‐frailty (aOR = 1.07; 95% CI = 1.00‐1.11) over time; Dentition was associated with worsening of impaired executive function‐frailty (aOR = 1.10; 95% CI = 1.02‐1.18) over time; Periodontal status was associated with worsening of impaired memory‐frailty (aOR = 1.07; 95% CI = 1.02‐1.13) and verbal fluency‐frailty (aOR = 1.05; 95% CI = 1.00‐1.11) over time. No significant associations were found for traditional cognitive frailty and impaired attention‐frailty.ConclusionCognitive frailty is associated with oral health after adjusting for covariates. Inspection of oral health is helpful to predict the risk of cognitive impairment at an early stage. Further research on this topic is warranted to validate our findings.