Abstract
BackgroundKillian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP.MethodsDNA from antral (n = 14) and nasal (n = 14) KP fractions were analyzed for HPV and HPyV sequences, genotypes, viral DNA load and physical status along with expression of viral proteins and p16 cellular protein.ResultsThe oncogenic HPV16 was detected in 3/14 (21.4%) antral KPs, whilst nasal KPs tested HPV-negative (0/14). The mean HPV16 DNA load was 4.65 ± 2.64 copy/104 cell. The whole HPV16 episomal genome was detected in one KP sample, whereas HPV16 DNA integration in two KPs. P16 mRNA level was lower in the KP sample carrying HPV16 episome than in KPs carrying integrated HPV16 and HPV- negative KPs (p< 0.001). None of the antral and nasal KP samples tested positive for HPyV DNA (0/28).ConclusionsA fraction of KP tested positive for the oncogenic HPV16. HPV16 detection in the KP antral portion may be consistent with HPV16 infection derived from the maxillary sinus. HPV16 DNA integration represents a novel finding. Altogether, these data improve our knowledge on the association between KP and HPV infection, whereas it indicates that the KP onset is heterogeneous.
Highlights
Killian polyp (KP), or antrochoanal polyp, is a benign lesion of the upper respiratory tract arising from the maxillary anthrum, which may extend through the nasal cavity to the choana
Prevalence of human papillomaviruses (HPV) and HPyV sequences DNAs isolated from KP tissue samples (n=28) represented by antral (n=14) and nasal (n=14) portions were tested for viral DNA sequences of HPV and HPyVs
The quantitative PCR (qPCR) analyses showed that 3/14 (21.4%) of the antral KP tissues were positive for HPV DNA (Table 2)
Summary
Killian polyp (KP), or antrochoanal polyp, is a benign lesion of the upper respiratory tract arising from the maxillary anthrum, which may extend through the nasal cavity to the choana. Several studies have suggested that autoreactivity, allergies and/ or chronic inflammation could be risk factors for KP onset [4,5,6]. Schryver et al questioned if autoreactivity contributed to the KP onset or it resulted from a chronic inflammation, and proposed to investigate other inflammation causes, such as viral infections [8]. Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP
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