Association between occupational stress and carotid atherosclerosis among the workers in a steel plant

Abstract

Objective: To investigate the association between occupational stress and carotid atherosclerosis among the workers in a steel plant. Methods: In October 2018, a total of 2947 workers from a steel plant, who underwent occupational health examination in the center for occupational health examination from March to May 2017, were selected as subjects. Job Content Questionnaire (JCQ) and Effort-Reward Imbalance (ERI) were used to investigate the job content and the degree of occupational stress. According to the results of carotid artery examination, the subjects were divided into normal carotid artery group with 2013 workers, increased carotid intima-media thickness (IMT) group with 277 workers, stable plaque group with 236 workers, and unstable plaque group with 421 workers. A unified questionnaire was distributed to each group, and related physical and biochemical examinations were performed. A multivariate unconditional logistic regression analysis was performed to investigate the risk factors for unstable plaque. Results: There were significant differences between the groups in sex, educational level, marital status, work in shifts, smoking, drinking, age, and working years (P<0.05) , while there was no significant difference in exercise between groups (P>0.05) . Based on the JCQ score, 761 (25.8%) had no stress, 959 (32.5%) had mild stress, 699 (23.7%) had moderate stress, and 528 (17.9%) had severe stress; based on the ERI score, 2526 (85.7%) had high effort and low reward and 421 (14.3%) did not have the high-effort and low-reward conditions. There was a significant difference in the composition of JCQ and ERI scores between groups (P<0.05) . Moderate stress (odds ratio [OR]=1.695) , severe stress (OR=5.443) , ERI (OR=7.391) , work in shift (OR=1.784) , old age (OR=1.009) , high systolic blood pressure (OR=1.105) , high fasting blood glucose (OR=1.212) , abnormal total cholesterol (OR=3.693) , abnormal apolipoprotein B (OR=39.215) , and abnormal high-sensitivity C-reactive protein (OR=1.632) were the risk factors for unstable plaque. Conclusion: Occupational stress may be involved in the development of carotid atherosclerosis.