Abstract
The association between obstructive lung disease and cardiovascular disease (CVD) has been suggested previously, but few studies have looked at this association in a diabetic cohort, a population highly susceptible to both comorbidities. A total of 1003 subjects in community practice settings were interviewed at home at the time of enrolment into the Vermont Diabetes Information System, a clinical decision support program. Patients self-reported their personal and clinical characteristics, including any obstructive lung disease. Laboratory data were obtained directly from the clinical laboratory. We performed a cross-sectional analysis of the interviewed subjects to assess a possible association between obstructive lung disease and CVD. In a multivariate logistic regression model, obstructive lung disease was significantly associated with CVD, even after correcting for potential confounders, including gender, obesity, low income, cigarette smoking, alcohol problems, and high comorbidity (odds ratio = 1.96; 95% confidence interval 1.37–2.81; p < 0.01). All components of CVD, including coronary artery disease (CAD), congestive heart failure (CHF), peripheral vascular disease (PVD), and cerebrovascular accidents (CVA), were also significantly associated with obstructive lung disease. These data suggest an association between obstructive lung disease and CVD in patients with diabetes. Future studies are needed to identify the mechanism supporting this association
Highlights
Published: 23 June 2021The burden of chronic respiratory diseases is increasing worldwide and, among these, the obstructive lung diseases asthma and chronic obstructive pulmonary disease (COPD)are among the main causes of mortality and morbidity [1]
Obstructive lung disease has been shown to have an association with many comorbidities [2,3,4,5], especially cardiovascular disease (CVD)
A more robust association is found in patients with COPD and CVD [6,7,8,9,10,11] than patients with asthma and CVD [12,13,14,15,16]
Summary
Published: 23 June 2021The burden of chronic respiratory diseases is increasing worldwide and, among these, the obstructive lung diseases asthma and chronic obstructive pulmonary disease (COPD)are among the main causes of mortality and morbidity [1]. The prevalence of COPD increases with age, as does the prevalence of comorbid conditions, while asthma is the most common chronic disease in children in Western countries, and it can be diagnosed at any age [2]. Obstructive lung disease has been shown to have an association with many comorbidities [2,3,4,5], especially cardiovascular disease (CVD). The mechanisms involved in the association between obstructive lung disease and cardiac disease are complex, but may be related to systemic inflammation, chronic infections, shared risk factors (such as smoking), or other undefined factors [17]. In the current cross-sectional study, we determined the association between obstructive lung disease and the prevalence of associated CVD using information obtained from the Vermont Diabetes Information System (VDIS) study
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