Abstract
BackgroundThe mechanism for possible association between obesity and poor clinical outcomes from Coronavirus Disease 2019 (COVID-19) remains unclear.MethodsWe analyzed 22,915 adult COVID-19 patients hospitalized from March 2020 to April 2021 to non-intensive care using the American Heart Association National COVID Registry. A multivariable Poisson model adjusted for age, sex, medical history, admission respiratory status, hospitalization characteristics, and laboratory findings was used to calculate length of stay (LOS) as a function of body mass index (BMI). We similarly analyzed 5,327 patients admitted to intensive care for comparison.ResultsRelative to normal BMI subjects, overweight, class I obese, and class II obese patients had approximately half-day reductions in LOS (–0.469 days, P<0.01; –0.480 days, P<0.01; –0.578 days, P<0.01, respectively).ConclusionThe model identified a dose-dependent, inverse relationship between BMI category and LOS for COVID-19, which was not seen when the model was applied to critically ill patients.
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