Abstract

Nodal and extranodal lymphomas are considered to be distinct entities on the basis of histological distribution, response to chemotherapy, and prognosis.1 The risk of non-Hodgkin's lymphoma is significantly increased in patients in an immunosuppressive state,2 and diabetes mellitus impairs the immune response to bacterial infections.3 We therefore retrospectively investigated the prevalence of diabetes mellitus in patients with nodal and extranodal lymphomas to determine whether the risk of lymphoma is increased in patients with diabetes. From 1986 to 1993, 160 patients with nodal and extranodal lymphoma, excluding those who were positive for human T cell leukaemia/lymphoma virus type I antibody, were treated at Kobe University School of Medicine Hospital. No patients were positive for HIV-1 antibody. We excluded 27 patients (21 with nodal lymphoma, six with extranodal lymphoma) because adequate …

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