Association between NOD2 gene polymorphisms and susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

Abstract

IntroductionTuberculosis (TB) in human societies is believed to be a major health menace and is considered as an important cause of morbidity and mortality worldwide. Nucleotide-binding oligomerization domain 2 (NOD2) is one of the pathogen recognition receptors (PRRs) that play its function in account of the recognition of peptidoglycans in bacterial cell wall. NOD2 gene polymorphisms could influence the levels of gene expression and may attribute to infections. MethodsThe present case-control study was conducted on 152 patients with pulmonary tuberculosis (PTB) and 162 healthy subjects to determine whether the NOD2 polymorphisms (rs2066842 and rs2066847) are associated with PTB. These polymorphisms were determined utilizing PCR-restriction fragment length polymorphism (PCR-RFLP). ResultsThe obtained results indicated that the NOD2 rs2066842 polymorphism under dominant/recessive model were associated with the increased susceptibility to PTB (P < 0.0001; OR = 2.988). No significant differences were found among the groups regarding rs2066847 polymorphism. ConclusionWe noticed that the NOD2 rs2066842 polymorphism but not rs2066847 polymorphism, provide a relative susceptibility factor for PTB patients in an Iranian population sample.