Abstract
Objective: The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with mortality risk in patients with hemodialysis (HD).
 Methods: We conducted a retrospective cohort study among regular HD patients at Wangaya Regional General Hospital. Data were collected from patients’ medical records in June 2018 and followed up until May 2019.
 Results: NLR and PLR were significantly associated with 1-year mortality (p=0.047 and p=0.009), with higher NLR (NLR>2.84) and higher PLR (PLR>10) associated with higher risk of 1-year mortality (relative risk [RR]=3.36 and RR=5.19).
 Conclusion: NLR and PLR were significantly associated with 1-year mortality in patients with HD.
Highlights
Patients with chronic kidney disease (CKD) who undergo regular hemodialysis (HD) have a higher risk of mortality compared to the general population
Definition of neutrophil-to-lymphocyte ratio (NLR) NLR was calculated as the ratio of the neutrophils and lymphocytes that obtained from the same laboratory result in June 2018, we collected from patients’ medical records
NLR and platelet-to-lymphocyte ratio (PLR) were significantly associated with 1-year mortality (p=0.047 and p=0.009), with higher NLR (NLR>2.84) and higher PLR (PLR>10) associated with higher risk of 1-year mortality (Table 2)
Summary
Patients with chronic kidney disease (CKD) who undergo regular hemodialysis (HD) have a higher risk of mortality compared to the general population. Neutrophil-to-lymphocyte ratio (NLR) had been studied in medical and surgical populations. It is a prognostic marker of morbidity and mortality for numerous conditions including cardiovascular disease (CVD), oncology, critical care medicine, liver disease, general surgery, and vascular surgery. It has been examined as a novel measure of inflammation in distinct populations and has been showed to have prognostic and predictive values, especially in those with systemic inflammation [2]. Many patients with CKD have increased serum levels of inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α, interleukin-6, and pentraxin-3. Very few studies have addressed the relationship between NLR and kidney disease progression in patients with CKD [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
