Association Between Myocarditis and Mortality in SARS-CoV-2 Patients in a Large Registry

Abstract

Background: This study investigates the relationship between SARS-CoV-2 infection and myocarditis. Myocarditis is assumed to be a negative prognostic factor without agreed-upon treatment. We present a large registry data assessing the association between myocarditis and mortality in patients with SARS-CoV-2 infection. Methods: The researchers identified adult patients aged 18-90 years with COVID-19 infections in the TriNetX (COVID-19 research network) database between January 20, 2020, and December 9, 2020. These patients were then divided into those who had a positive myocarditis diagnosis and those who did not. The researchers compared all-cause mortality between propensity-matched (PSM) pairs of patients in both groups. Results: Total of 259,352 patients with COVID-19 diagnosis were included in the study. Of those patients, 383 (0.01%) had myocarditis diagnosis, while 258,969 (99.9%) did not have myocarditis diagnosis during their hospital stay. Patients were more male in the myocarditis group (58.75% vs. 44.73%, P P P Conclusion: In a large multinational database of SARS-CoV-2 patients, we observed an association between myocarditis diagnosis and increased mortality. Further prospective studies are recommended to further assess myocarditis outcomes in COVID-19 patients and treatment options.Funding Statement: None to declare. Declaration of Interests: None to declare. Ethics Approval Statement: This is study was approved by the Charleston Area Medical Center Institutional Review Boards IRB (17-348).