Association between myeloperoxidase polymorphism (MPO-129G/A), oxidized low-density lipoprotein level, and atherogenic indices in patients with atherosclerosis; a case-control study

Abstract

ObjectiveThis study aimed to evaluate the correlation between myeloperoxidase polymorphism (MPO-129G/A) and the risk of atherosclerosis and its association with oxidized low-density lipoprotein (Ox-LDL) levels and atherogenic indices. Materials and methodsThe present study was performed on 255 subjects, including 125 controls and 130 atherosclerotic patients. To determine MPO-129G/A polymorphism, the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method was utilized. Serum lipid profile levels and fasting blood sugar (FBS) level were calculated using an auto-analyzer. Atherogenic indices and Ox-LDL levels were measured using formulae and ELISA method, respectively. ResultsThe findings illustrated no considerable difference between the patient and control groups concerning MPO-129G/A genotypes (p > 0.05). There was no substantial relationship between MPO-129G/A genotypes, Ox-LDL levels, and atherogenic indices in the patient group (p > 0.05), while patients possessed considerably higher Ox-LDL level and atherogenic indices (p < 0.05). In addition, CRI-II (LDL/HDL) was significantly correlated with Ox-LDL (p = 0.001) and FBS (p = 0.0007). ConclusionMPO-129G/A indicated no association with Ox-LDL levels and atherogenic indices. However, atherosclerotic patients had higher Ox-LDL levels and atherogenic indices. Furthermore, CRI-II was significantly correlated with levels of Ox-LDL and blood glucose, suggesting a strong marker for predicting the risk of atherosclerosis.