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Abstract
Colorectal cancer (CRC) is one of the most common and lethal types of cancer worldwide. The developing of this disease includes many factors such as genetic, socioeconomic, environmental, and lifestyle factors, and nutrition habits. The aim of the study is the determination of zearalenone and its metabolite level in the biological samples of participants at risk of CRC, in relation to the nutrition data and information on the quality of life dependent on health. In the cohort clinical trial, 150 participants aged between 50 and 65 will be studied. The participants will be assigned into two groups depending on the colonoscopy result. Participants will be tested at dietary intake, quality of life, sleep time and quality, stress level as well as biochemical parameters of the blood. Moreover, in the biological samples, concentration of zearalenone and its metabolites (α-zearalenol and β-zearalenol) as well as the characteristics of gastrointestinal bacterial will be determined, and the end of the trial for both groups and their results will be compared. Taking into account the possible effect of mycotoxins and nutrition habits on the development of cancer, the results obtained may allow the formulation of new nutritional recommendations and reduce the development and occurrence of CRC.
Highlights
Colorectal cancer is one of the most diagnosed cancers
The aim of the study is the determination of zearalenone and its metabolite (α and β) level in the blood plasma and feces of participants at increased risk of cancer, in relation to the nutrition data (FFQ) and information on the quality of life dependent on health (WHOQOL-BREF)
To the best of our knowledge, only scarce information regarding the level of zearalenone and its metabolites (α-zearalenol and β-zearalenol) and development of various type of cancer has been reported in literature so far [16,17]
Summary
Colorectal cancer is one of the most diagnosed cancers. It is the second most often detected cancer in females and the third in males [1,2,3]. The incidence of colorectal cancer (CRC) depends on the industrialization and high-developed of a given geographical region. The reasons for the development of CRC are complex and related to genetic, socio-economic, environmental, and lifestyle factors as well as nutrition habits [5,6,7]. It is still unknown why the incidence of colorectal cancer is higher in the more developed countries [4].
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