Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis

Jiaxuan Qin,Jinchun Xing,Wei Li,Kaiyan Zhang,Zhun Wu

doi:10.1080/0886022x.2018.1499529

Jiaxuan Qin, Jinchun Xing + Show 3 more

Open Access

https://doi.org/10.1080/0886022x.2018.1499529

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Abstract

Background/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association.Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis.Conclusions: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.

Highlights

Myeloperoxidase (MPO) is an oxidative lysosomal enzyme that is available in polymorphonuclear neutrophils and monocytes
In group ORD, ORD plus, overall and overall plus, we found MPO -463G > A was not associated with chronic kidney disease (CKD) susceptibility in recessive model (AA vs. GG þ GA) and homozygote comparison (AA vs. GG), and the results showed stability in sensitivity analyses and no publication bias
In group ORD, ORD plus, overall and overall plus, we found MPO -463G > A was associated with increased risk of CKD in allelic comparison (A vs. G), heterozygote comparison (GA vs. GG) and dominant model (GA þ AA vs. GG), the results lacked stability

Summary

Introduction

Myeloperoxidase (MPO) is an oxidative lysosomal enzyme that is available in polymorphonuclear neutrophils and monocytes. MPO utilizes H2O2 to generate hypochlorous acid (HClO) and other reactive moieties, which kill pathogens during infections. In the setting of sterile inflammation, MPO and MPO-derived oxidants are thought to be pathogenic, promoting inflammation and causing tissue damage [1]. Patients with chronic kidney disease (CKD) have a number of disorders in the organism. Chronic inflammation joined with oxidative stress contributes to the development of numerous complications: accelerated atherosclerosis process and cardiovascular disease, emergence of type 2 diabetes mellitus, development of malnutrition, anemia, hyperparathyroidism, and so forth, affecting the prognosis and quality of life of patients with CKD [2]. Peripheral blood myeloperoxidase activity increases during hemodialysis [3]

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