Abstract
MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings.
Highlights
Liver cancer is one of the most common malignant tumors in the world
We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for Hepatocellular carcinoma (HCC) (OR = 0.24, 95% confidence intervals (CIs) = 0.06–0.96, P = 0.043)
Compared with individuals carrying the wild-type genotype AA of MET rs1621, those individuals carrying the variant genotype GG had a decreased risk of HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043)
Summary
Liver cancer is one of the most common malignant tumors in the world. Hepatocellular carcinoma (HCC) accounts for 85% to 90% of the primary liver cancer. China is a country with a high incidence of liver cancer. It was estimated that approximately 50% of the new cases and death cases in world occurred in China [1]. The etiology of HCC is multifactorial, and chronic hepatitis B virus (HBV) infection is a major cause of HCC. The fact that only a small proportion of patients with chronic HBV infection eventually develop HCC suggests that genetic predisposition may play an important role in the development of HCC [2,3,4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
