Association between miR-124 rs531564 and miR-100 rs1834306 polymorphisms and cervical cancer: a meta-analysis

Abstract

Aim: To explore the correlations between miR-124 rs531564 and miR-100 rs1834306 polymorphisms and cervical cancer (CC). Materials and Methods: Relevant studies were searched from the electronic databases Embase, Cochrane library, and PubMed updated to January 2017, as well as through literature tracing. Studies were selected based on strict criteria, followed by the included studies which were conducted with quality assessment using Newcastle-Ottawa Scale (NOS). With odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) as effect indicators, meta-analysis for exploring the correlations between rs531564 and rs1834306 polymorphisms and CC was performed using R 3.12 software. Using Egger’s test, publication bias was elevated for the included studies. In addition, sensitivity analysis was carried out. Results: There were a total of four eligible studies, involving 3,707 participators (including 1,592 CC patients and 2,115 healthy controls). The NOS scores of the included studies were 5-7, indicating a high quality. Meta-analysis showed that all genetic models of rs531564 were statistically significant (p < 0.05), indicating that rs531564 was associated with the occurrence of CC. Nevertheless, the situation for rs1834306 was exactly the opposite. Egger’s test for rs531564 showed no publication bias, suggesting that our results were reliable. Sensitivity analysis showed that the pooled results of rs531564 were stable in general. Conclusion: These indicated that rs531564 was correlated with the development of CC, but not rs1834306.