Abstract
Background: Endometrial cancer is one of the most common cancers of the female reproductive system, and it is one of the rise globally. metabolic syndrome is a clustering of at least three of the five following medical conditions: central obesity, diabetes, hypertension, high serum triglyceride and low serum high density lipoprotein. Aim: The aim of this study was to assess the association between the metabolic syndrome and the endometrial cancer. Methods: this case control study comprised of 93 patients with abnormal uterine bleeding admitted to department of obstetrics and gynecology, Tishreen University Hospital, Lattakia Syria, during the period of February 2019 To February 2021, patients who full field the inclusion criteria for the study were divided into 2 groups, the first consisted of 31 patients had endometrial cancer with histological confirmation (cases). The second consisted of 62 patients with normal biopsies (controls). The determination of the metabolic syndrome is according to NCEP ATP III(2005) Results: Baseline characteristics were matched in both study groups. In assessment the association between the metabolic syndrome and the endometrial cancer the odd ratio (OR) was (3.31). the odd ratio (OR) for metabolic syndrome (MS) elements were (2.9 with diabetes, 3.9 with obesity, 2.05 with hypertension, 2.36 with high triglyceride and 1.2 with low high density lipoprotein). Conclusion: the metabolic syndrome and its elements are causes of endometrial cancer.
Highlights
[6] Diagnosis: Metabolic syndrome is diagnosed when there is 3 of 5 criteria according to NCEP ATP III(2005) 1- Fasting blood sugar ≥100 mg \dl. 2- Blood pressure ≥ 130\80 mmz. 3- Tri gleceride (TG) ≥150 mg\dl. 4- High rensity lipoprotine (HDL)≤ (50) mg\dl. 5- Body mass index (BMI) ≥30 KG\ M
Table [1] gives the distribution of 31 cases of endometrial cancer and 62 controls according to sociodemographic variables, cases and controls had similar distribution according to age and menopausal status, compared with controls cases had lower age at menarche and lower parity
The obesity had the highest risk of endometrial cancer with odd ratio (OR) = 3.9 that can be explained by the high estrogen level produced by aromatase enzymes and the role of adipose tissue in secretion some elements had a role in malignant tissue development. [12]
Summary
Endometrial cancer (EC): is a glandular malignancy in the epithelium of the uterine endothelium caused by unopposed estrogen excitation, it is common after the menopause, the mean age is 63 years. [1]. Endometrial cancer (EC): is a glandular malignancy in the epithelium of the uterine endothelium caused by unopposed estrogen excitation, it is common after the menopause, the mean age is 63 years. The women in families who had lynch syndrome are high risk for endometrial cancer. [5] Metabolic syndrome is a risk factor of cardiac disease and many cancers. The exact mechanism of the role of metabolic syndrome in endometrial cancer is unknown, it has an association of high of this metabolite like glucose and triglyceride. AIM: The objective of this study was to assess the association between metabolic syndrome endometrial cancer. IMPORTANCE OF THE STUDY: Endometrial cancer is associated with globally significant morbidity and mortality, since there are no screening programs for this disease risk, modification strategies allow controlling its incidence. The result is satistically significant when P- value 5% and odd ratio ≥2. the variables adjusted for age, age, at menarche, parity and menopausal status. 5- Ethical Considerations: Approval of the study from faculty of medicine to Tishreen Hospital manager
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
