Association between mean platellet volume levels and mortality outcomes in geriatric patients in intensive care

Abstract

To prospectively evaluate the relationship between Mean Platelet Volume (MPV) levels and short-term mortality outcomes in critically ill patients aged ≥85 years. We hypothesized that abnormal MPV levels could offer actionable insights for predicting mortality risk in this highly vulnerable group, thereby improving therapeutic decision-making processes in the ICU setting. This study included patients aged ≥85 years. The participants were categorized into two groups based on their MPV levels at admission: group 1 (MPV≤12.5, normal range) and group 2 (MPV>12.5, elevated).A comprehensive set of variables, including demographic information, clinical indices, biochemical parameters, and respiratory metrics, were recorded. In a cohort of 475 participants, patients were stratified into two distinct groups based on MPV values: group 1 (n=400, 84.2%) and group 2 (n=75, 15.8%). The mean age was 89 (SD=7.7) and 88 (SD=6.2) years for group 1 and group 2, respectively, with a statistically significant difference (p=0.035). Significant differences were found in key biochemical parameters such as urea (p=0.045) and sodium (p=0.005). The most profound disparity was observed in platelet counts, with a highly significant p-value <0.001. The clinical outcomes showed a substantial divergence in the 30-day mortality rates between the two MPV-based cohorts (p<0.001). Additionally, a higher incidence of sepsis was recorded in the Group 2 (p=0.024). MPV is a significant prognostic indicator for mortality, 30-day mortality, and sepsis incidence, advocating its inclusion in routine clinical assessments to optimize patient care. Routinely accessible platelet indices serve as robust indicators for assessing both morbidity and mortality in critically ill patients.